Extended duration of prehydration does not prevent nephrotoxicity or delayed drug elimination in high-dose methotrexate infusions: a prospectively randomized cross-over study

Torben Stamm Mikkelsen; Aissata Diop Mamoudou; Ruta Tuckuviene; Peder Skov Wehner; Henrik Schroeder

doi:10.1002/pbc.24623

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Extended duration of prehydration does not prevent nephrotoxicity or delayed drug elimination in high-dose methotrexate infusions: a prospectively randomized cross-over study

Research output: Contribution to journal › Journal article › Research › peer-review

DOI

https://doi.org/10.1002/pbc.24623

Torben Stamm Mikkelsen
Aissata Diop Mamoudou
Ruta Tuckuviene
Peder Skov Wehner
Henrik Schroeder

Paediatrics

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Alkalized hydration is used as supportive care to prevent renal toxicity during infusions with high-dose methotrexate (HDMTX). In children with acute lymphoblastic leukemia (ALL), the hydration is commonly initiated 4 hours before start of the methotrexate (MTX) infusion. To test if longer duration of prehydration would prevent MTX-induced renal toxicity, we preformed a randomized cross-over study comparing 12-4 hours of hydration before the infusion of HDMTX.

Language	English
Journal	Pediatric Blood & Cancer
Volume	61
Issue number	2
Pages (from-to)	297-301
ISSN	1545-5009
DOIs	10.1002/pbc.24623
Publication status	Published - Feb 2014

Research areas

Adolescent, Adult, Antimetabolites, Antineoplastic, Child, Child, Preschool, Combined Modality Therapy, Cross-Over Studies, Female, Fluid Therapy, Follow-Up Studies, Humans, Infant, Infusions, Intravenous, Kidney Diseases, Lymphoma, Non-Hodgkin, Male, Methotrexate, Neoplasm Staging, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Prospective Studies, Time Factors, Tissue Distribution, Young Adult