Echinocandin Failure Case Due to a Previously Unreported FKS1 Mutation in Candida krusei

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Echinocandins are the preferred therapy for invasive infections due to Candida krusei. We present here a case of clinical failure involving C. krusei with a characteristic FKS1 hot spot mutation not previously reported in C. krusei that was isolated after 14 days of treatment. Anidulafungin MICs were elevated by ≥5 dilution steps above the clinical breakpoint but by only 1 step for a Candida albicans isolate harboring the corresponding mutation, suggesting a notable species-specific difference in the MIC increase conferred by this mutation.

LanguageEnglish
JournalAntimicrobial Agents and Chemotherapy
Volume58
Issue number6
Pages (from-to)3550-3552
ISSN0066-4804
DOIs
StatePublished - Jun 2014