Elisabeth Rexen Ulven

Elisabeth Rexen Ulven

Elisabeth Rexen Ulven

Assistant Professor

Phone: 65503517Fax: 66158760

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Elisabeth Rexen Ulven

Assistant Professor

  • Department of Physics, Chemistry and Pharmacy

Email: elc@sdu.dk

Fax: 66158760

Phone: 65503517

Education & Employment

Sep 2015-Assistant professor in Medicinal Chemistry, University of Southern Denmark
Sep 2015-Visiting researcher, The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
Dec 2014-Lecture training program, University of Southern Denmark
Jan 2012-Aug2015Postdoc, FFARMED, University of Southern Denmark
Mar 2012Ph.D. Medicinal Chemistry, University of Southern Denmark
Feb-Mar 2011Research stay, Laboratory of Computational Medicine, Universitat Autónoma de Barcelona, Spain
Nov 2008Cand.Sc. Pharmaceutical Chemistry, University of Southern Denmark

Publications

Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum

Domljanovic, I., Rexen Ulven, E., Ulven, T., Thomsen, R. P., Okholm, A. H., Kjems, J., Voss, A., Taskova, M. & Astakhova, K., 2018, In : ACS Omega. 3, 7, p. 7580-7586

Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1

Rexen Ulven, E., Trauelsen, M., Brvar, M., Lückmann, M., Bielefeldt, L., Jensen, L. K. I., Schwartz, T. W. & Frimurer, T. M., 2018, In : Scientific Reports. 8, 18 p., 10010

Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)

Hansen, A. H., Sergeev, E., Pandey, S. K., Hudson, B. D., Rexen Ulven, E., Milligan, G. & Ulven, T., 2017, In : Journal of Medicinal Chemistry. 60, 13, p. 5638-5645

Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

Dragano, N. R. V., Solon, C., Ramalho, A. F., de Moura, R. F., Razolli, D. S., Christiansen, E., Goncalves de Azavedo, C. M. B. P., Ulven, T. & Velloso, L. A., 2017, In : Journal of Neuroinflammation. 14, 16 p., 91

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

Trauelsen, M., Rexen Ulven, E., Hjorth, S. A., Brvar, M., Monaco, C., Frimurer, T. M. & Schwartz, T. W., 2017, In : Cell Metabolism. 6, 12, p. 1585-1596

Structure-based Discovery of Novel US28 Small Molecule Ligands with Different Modes of Action

Lückmann, M., Amarandi, R-M., Papargyri, N., Jakobsen, M. H., Christiansen, E., Jensen, L. J., Pui, A., Schwartz, T. W., Rosenkilde, M. M. & Frimurer, T. M., 2017, In : Chemical Biology & Drug Design. 89, 3, p. 289–296

Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy

Hansen, S. V. F., Christiansen, E., Urban, C., Hudson, B. D., Stocker, C. J., Due-Hansen, M. E., Wargent, E. T., Shimpukade, B., Almeida, R., Ejsing, C. S., Cawthorne, M. A., Kassack, M. U., Milligan, G. & Ulven, T., 1 Mar 2016, In : Journal of Medicinal Chemistry. 59, 6, p. 2841-2846

Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer

Christiansen, E., Hudson, B. D., Hansen, A. H., Milligan, G. & Ulven, T., 2016, In : Journal of Medicinal Chemistry. 59, 10, p. 4849-4858

Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity

Goncalves de Azavedo, C. M. B. P., Watterson, K. R., Wargent, E. T., Hansen, S. V. F., Hudson, B. D., Kępczyńska, M. A., Dunlop, J., Shimpukade, B., Christiansen, E., Milligan, G., Stocker, C. J. & Ulven, T., 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 8868-8878

Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120

Ulven, T. & Christiansen, E., 17 Jul 2015, In : Annual Review of Nutrition. 35, p. 239-63

Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

Christiansen, E., Watterson, K. R., Stocker, C. J., Sokol, E., Jenkins, L., Simon, K., Grundmann, M., Petersen, R. K., Wargent, E. T., Hudson, B. D., Kostenis, E., Ejsing, C. S., Cawthorne, M. A., Milligan, G. & Ulven, T., 2015, In : The British Journal of Nutrition. 113, 11, p. 1677-1688 12 p.

Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands

Hudson, B. D., Christiansen, E., Murdoch, H., Jenkins, L., Hansen, A. H., Madsen, O., Ulven, T. & Milligan, G., Aug 2014, In : Molecular Pharmacology. 86, 2, p. 200-10 11 p.

In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469

Urban, C., Hamacher, A., Partke, H. J., Roden, M., Schinner, S., Christiansen, E., Due-Hansen, M. E., Ulven, T., Gohlke, H. & Kassack, M. U., 17 Jul 2013, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 386, 12, p. 1021-2030

Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

Hudson, B. D., Due-Hansen, M. E., Christiansen, E., Hansen, A., Mackenzie, A. E., Murdoch, H., Pandey, S. K., Ward, R. J., Marquez, R., Tikhonova, I. G., Ulven, T. & Milligan, G., 14 Jun 2013, In : Journal of Biological Chemistry. 288, p. 17296-17312

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes

Christiansen, E., Hansen, S. V. F., Urban, C., Hudson, B. D., Wargent, E. T., Grundmann, M., Jenkins, L., Zaibi, M., Stocker, C. J., Ullrich, S., Kostenis, E., Kassack, M. U., Milligan, G., Cawthorne, M. A. & Ulven, T., 9 May 2013, In : A C S Medicinal Chemistry Letters. 4, 5, p. 441-445 5 p.

Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability

Christiansen, E., Due-Hansen, M. E., Urban, C., Grundmann, M., Schmidt, J., Hansen, S. V. F., Hudson, B. D., Zaibi, M., Markussen, S. B., Hagesaether, E., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, T., 14 Feb 2013, In : Journal of Medicinal Chemistry. 56, 3, p. 982-92 11 p.

Reevaluation of Fatty acid receptor 1 (FFAR1/GPR40) as drug target for the stimulation of insulin secretion in humans

Wagner, R., Kaiser, G., Gerst, F., Christiansen, E., Due-Hansen, M. E., Grundmann, M., Machicao, F., Peter, A., Kostenis, E., Ulven, T., Fritsche, A., Häring, H-U. & Ullrich, S., 1 Feb 2013, In : Diabetes. 62, 6, p. 2106-2111

Mucus can change the permeation rank order of drug candidates

Hagesaether, E., Christiansen, E., Due-Hansen, M. E. & Ulven, T., 2013, In : International Journal of Pharmaceutics. 452, 1-2, p. 276-282

The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

Hudson, B. D., Shimpukade, B., Mackenzie, A. E., Butcher, A. J., Pediani, J. D., Christiansen, E., Heathcote, H., Tobin, A. B., Ulven, T. & Milligan, G., 2013, In : Molecular Pharmacology. 84, 5, p. 710-25

Preparation of ortho-fluoro substituted compounds for the treatment of metabolic diseases.

Ulven, T. & Christiansen, E., 11 Oct 2012, Patent No. WO 2012/136221A1

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

Hudson, B. D., Christiansen, E., Tikhonova, I. G., Grundmann, M., Kostenis, E., Adams, D. R., Ulven, T. & Milligan, G., 2012, In : F A S E B Journal. 26, 12, p. 4951-4965

Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists: Mesylpropoxy Appendage Lowers Lipophilicity and Improves ADME Properties

Christiansen, E., Due-Hansen, M. E., Urban, C., Grundmann, M., Schröder, R., Hudson, B. D., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, T., 2012, In : Journal of Medicinal Chemistry. 55, 14, p. 6624-8 5 p.

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

Schmidt, J., Smith, N. J., Christiansen, E., Tikhonova, I. G., Grundmann, M., Hudson, B. D., Ward, R. J., Drewke, C., Milligan, G., Kostenis, E. & Ulven, T., 10 Jan 2011, In : Journal of Biological Chemistry. 286, 12, p. 10628-40 13 p.

Conjugated Linoleic Acids Mediate Insulin Release through Islet G Protein-coupled Receptor FFA1/GPR40

Schmidt, J., Liebscher, K., Merten, N., Grundmann, M., Mielenz, M., Sauerwein, H., Christiansen, E., Due-Hansen, M. E., Ulven, T., Ullrich, S., Gomeza, J., Drewke, C. & Kostenis, E., 2011, In : Journal of Biological Chemistry. 286, 14, p. 11890-4 5 p.

Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties

Christiansen, E., Urban, C., Grundmann, M., Due-Hansen, M. E., Hagesaether, E., Schmidt, J., Pardo, L., Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, T., 2011, In : Journal of Medicinal Chemistry. 54, 19, p. 6691-6703

A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists

Christiansen, E., Due-Hansen, M. E. & Ulven, T., 19 Feb 2010, In : Journal of Organic Chemistry. 75, 4, p. 1301-4 3 p.

Compounds for the treatment of metabolic diseases

Ulven, T. & Christiansen, E., 4 Feb 2010, Patent No. WO 2010/012650, 4 Feb 2010

Structure−Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469

Christiansen, E., Due-Hansen, M. E., Urban, C., Merten, N., Pfleiderer, M., Karlsen, K. K., Rasmussen, S. S., Steensgaard, M., Hamacher, A., Schmidt, J., Drewke, C., Petersen, R. K., Kristiansen, K., Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, T., 2010, In : A C S Medicinal Chemistry Letters. 1, 7, p. 345-349 5 p.

Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes

Christiansen, E., Urban, C., Merten, N., Liebscher, K., Karlsen, K., Hamacher, A., Spinrath, A., Bond, A., Drewke, C., Ullrich, S., Kassack, M., Kostenis, E. & Ulven, T., 24 Oct 2008, In : Journal of Medicinal Chemistry. 51, 22, p. 7061-7064 4 p.